RARECHEM AL BL 0044
3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid
CAS: 299165-24-5
Molecular Formula: C10H10F3NO2
RARECHEM AL BL 0044 - Names and Identifiers
RARECHEM AL BL 0044 - Physico-chemical Properties
| Molecular Formula | C10H10F3NO2 |
| Molar Mass | 233.19 |
| Density | 1.361g/cm3 |
| Boling Point | 308.7°C at 760 mmHg |
| Flash Point | 140.5°C |
| Vapor Presure | 0.000289mmHg at 25°C |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.501 |
RARECHEM AL BL 0044 - Introduction
3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid is an organic compound with the chemical formula C10H9F3NO2. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid is a colorless crystal or white crystalline powder.
-Solubility: It has low solubility in water, but has good solubility in organic solvents (such as alcohols, ethers and ketones).
-Melting point: approximately 152-155°C.
Use:
3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid has a variety of uses in the chemical and pharmaceutical fields, including:
-As a reagent and catalyst in organic synthesis.
-As a drug intermediate, used in the synthesis of anti-acidic and anti-inflammatory drugs.
Method:
The preparation of 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid can be carried out by the following steps:
1. First, 2-trifluoromethylphenyl methyl ether and sodium cyanide were reacted in the presence of ammonia gas to obtain 2-amino -2-(2-trifluoromethylphenyl) acetonitrile.
2. Then, 2-amino -2-(2-trifluoromethylphenyl) acetonitrile is reacted with hydrogen in the presence of a palladium catalyst, 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid is obtained.
Safety Information:
The specific hazards and safety of 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid need further experiments and studies. When handling and using the compound, it is necessary to follow appropriate laboratory safety practices and use personal protective equipment, such as laboratory gloves and protective glasses.
Nature:
-Appearance: 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid is a colorless crystal or white crystalline powder.
-Solubility: It has low solubility in water, but has good solubility in organic solvents (such as alcohols, ethers and ketones).
-Melting point: approximately 152-155°C.
Use:
3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid has a variety of uses in the chemical and pharmaceutical fields, including:
-As a reagent and catalyst in organic synthesis.
-As a drug intermediate, used in the synthesis of anti-acidic and anti-inflammatory drugs.
Method:
The preparation of 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid can be carried out by the following steps:
1. First, 2-trifluoromethylphenyl methyl ether and sodium cyanide were reacted in the presence of ammonia gas to obtain 2-amino -2-(2-trifluoromethylphenyl) acetonitrile.
2. Then, 2-amino -2-(2-trifluoromethylphenyl) acetonitrile is reacted with hydrogen in the presence of a palladium catalyst, 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid is obtained.
Safety Information:
The specific hazards and safety of 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid need further experiments and studies. When handling and using the compound, it is necessary to follow appropriate laboratory safety practices and use personal protective equipment, such as laboratory gloves and protective glasses.
Last Update：2024-04-09 21:01:54
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CAS: 299165-24-5
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CAS: 299165-24-5
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